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Furthermore, given that the effects of 5-HT 2C agonists also include weight loss and a reduction in reward-seeking behaviors, the use of compounds that enhance 5-HT 2C signaling would also be clinically relevant for the treatment of obesity or to prevent relapse to drug abuse
In the landmark study that introduced it, published in Cell Metabolism (Lee et al., 2015), researchers showed that MOTS-c regulates insulin sensitivity and metabolic homeostasis through the AMPK pathway, and that treatment prevented diet-induced obesity and insulin resistance in animal models
TemelJSAbernethyAPCurrowDCFriendJDuusEMYanYet al
other peptides (Sermorelin, Ipamorelin, Epitalon) act indirectly via GH or melatonin pathways